Mechanistic modelling for ecotoxicology and ecology

DEBtox Researc

Welcome to DEBtox Research

DEBtox Research is the private company that I (Tjalling Jager) operate since January 2015 to offer my knowledge and expertise on mechanistic modelling to customers. My mission is to increase the scientific foundation of ecotoxicology, environmental risk assessment, and life-history ecology, by the application of mechanistic models. Mechanistic modelling attempts to provide a (simplistic) explanation for the observed behaviour of the organism, rather than just describing it. Thereby, we gain a deeper understanding of the organism and the stressors affecting it. In turn, this understanding can help us to make educated extrapolations to untested situations.

My specialty is in the development and application of toxicokinetic and toxicodynamic models (at the level of the individual), in particular models based on Dynamic Energy Budget (DEB) theory and the General Unified Threshold model for Survival (GUTS). These models can be applied to a wide range of species (basically: all), and an enormous range of fundamental and applied research questions. More information on the type of activities that I have to offer can be found on the activities page.

I also maintain the site, which contains much more detailed information about these models, as well as free e-books, software, and lists of relevant publications. This website is dedicated to my project activities.


  • Roman Ashauer and myself will be collaborating in a CEFIC-LRI funded project centered on GUTS. More details will follow by the end of 2016.
  • The summer course on dynamic modelling of toxic effects was held 9-16 August 2016 in Denmark. We plan to give the course again 2018. More information.
  • 11-21 August 2015: the latest versions of my e-books "Making sense of chemical stress" and "DEBkiss" are now published with the Leanpub publishing framework. They can be downloaded over here and here. Paying for them is optional, but will allow me to dedicate time to providing updates, and writing other books.
  • As of 7 August 2015, I moved my DEBtox Research activities from to this website. The info site will then be strictly information, and my commercial activities and projects will be located here.

DEBtox Research,, Chamber of Commerce Utrecht 62405055, email: tjalling (at)