Mechanistic modelling for ecotoxicology and ecology

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Mixtures - Classic and temporal mixture synergism in terrestrial ecosystems: Prevalence,
mechanisms and impacts


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Funding
National Environmental Research Council (UK)
Duration
2018-2022
Project leader
CEH-UK (David Spurgeon), University of York (Roman Ashauer, Alistair Boxall)

Description

Aim of this project is to investigate the detailed mechanisms through which mixtures of pesticides and other chemicals affect terrestrial invertebrates. Comprising researchers from CEH, University of Cardiff, University of York and Imperial College, this project will look at synergism – where the interaction between various chemicals has a greater impact than the individual effects added together. We will use a range of ecological, analytical, genetic and modelling methods to identify cases where a mixture of exposures results in greater effects than can be predicted by current widely used models, the biological causes of such effects and their impact on invertebrate populations and communities.

My role

Collaborating with the postdoc (Sylvain Bart) in the development and application of toxicokinetic-toxicodynamic model (i.e., GUTS and DEBtox). Specifically the model extensions to deal with mixture toxicity and the statistical apsects of parameter estimation, uncertainty quantification, and error propagation. I am advising on the data analysis and in the preparation of scientific publications.





Output: Publications (as first or co-author)

  • Bart S, T Jager, A Robinson, E Lahive, D Spurgeon and R Ashauer (acc.). Predicting mixture effects over time with toxicokinetic-toxicodynamic models (GUTS): assumptions, experimental testing & predictive power. Accepted in Environmental Science & Technology (18 Jan. 2021).
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Output: Presentations (as presenter and as contributor)

  • Predicting mixture toxicity effects over time with toxicokinetic-toxicodynamic models (GUTS): assumptions, experimental testing & predictive power. Bart S, T Jager, A Robinson, C Badder, E Lahive, H Hesketh, DJ Spuregon and R Ashauer. Poster presentation by Sylvain Bart at the 30th SETAC Europe conference in virtual space, 3-7 May 2020.
  • General Unified Threshold Model of Survival (GUTS) – Extending the toxicokinetic-toxicodynamic framework for interaction analyses (synergism and antagonism). Bart S, T Jager, A Robinson, C Badder, E Lahive, C Svendsen, DJ Spurgeon and R Ashauer. Submitted as platform presentation for the 31st SETAC Europe conference in virtual space, 3-6 May 2021.
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