Description
The network consisted of 13 partner institutions and 10
associated partners from industry, regulatory authorities,
and contract research organizations. CREAM included 20 PhD
and three postdoc projects. All projects were related to
developing ecological models for the risk assessment of
chemicals, primarily pesticides. Since empirical approaches
are too limited to solve the problems, mechanistic effect
models are needed to make chemical risk assessment more
ecologically relevant. To make this possible, CREAM is
designed to (1) develop guidance for Good Modelling Practice
which makes modelling more transparent, consistent,
comprehensive, and reliable; (2) test and demonstrate the
added value of models in a number of case studies; (3) train
more researchers in both modelling and regulatory risk
assessment so they can be involved in future model-based
risk assessments in academia, industry, and regulatory
authorities.
My role
(co-)supervision of four PhD students at VU (Amsterdam, The
Netherlands), UFZ (Leipzig, Germany), JU (Krakow, Poland)
and INRA (Rennes, France). Application of the standard DEB
model to toxic effects, development of simplified DEB
models, and harmonisation of survival models into GUTS.
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Output: PHD theses (as supervisor)
- E. I. Zimmer: “The pond snail under stress.
Interactive effects of food limitation, toxicants and
copulation explained by Dynamic Energy Budget theory.”
Defense 18 June 2013. Download
thesis from ThB website. Collaboration with
Virginie Ducrot, INRA,
Rennes, France.
- B. T. Martin: “Linking individual-based modelling and
Dynamic Energy Budget theory: lessons for ecology and
ecotoxicology.” Defense 18 June 2013. Download
thesis from VU-DARE. Collaboration with Volker
Grimm, UFZ,
Leipzig, Germany.
- N. T. Hamda: “Mechanistic models to explore combined
effects of toxic chemicals and natural stressing
factors: case study on springtails.” Defense 10 February
2014. Download
thesis from VU-DARE. Collaboration with Ryszard
Laskowski, Jagiellonian
University, Krakow, Poland.
- A. Barsi: “Risk assessment of endocrine disrupting
pesticides in gastropods.” Defense: 14 January
2015. Download
thesis from VU-DARE. Collaboration with Virginie
Ducrot and Laurent Lagadic, INRA, Rennes,
France.
Output: Publications (as first or co-author)
- Jager T and C Klok (2010). Extrapolating toxic effects
on individuals to the population level: the role of
dynamic energy budgets. Phil Trans R Soc B
365:3531-3540. DOI
10.1098/rstb.2010.0137
- Ashauer R, Agatz A, Albert C, Ducrot V, Galic N,
Hendriks J, Jager T, Kretschmann A, O’Connor I, Rubach
MN, Nyman A-M, Schmitt W, Stadnicka J, van den Brink PJ
and Preuss TG (2011). Toxicokinetic-toxicodynamic
modelling of quantal and graded sub-lethal endpoints - a
brief discussion of concepts. Environ Toxicol Chem.
30(11):2519-2524. DOI
10.1002/etc.639
- Jager T, Albert C, Preuss TG and Ashauer R (2011).
General Unified Threshold model of Survival - a
toxicokinetic-toxicodynamic framework for ecotoxicology.
Environ Sci Technol 45:2529-2540. DOI
10.1021/es103092a
- Jager T and Selck H (2011). Interpreting toxicity data
in a DEB framework; a case study for nonylphenol in the
marine polychaete Capitella teleta. J Sea Res
66:456-462 DOI
10.1016/j.seares.2011.04.003
- Jager T and Zimmer EI (2012). Simplified Dynamic
Energy Budget model for analysing ecotoxicity data.
Ecol. Mod. 225:74-81 DOI
10.1016/j.ecolmodel.2011.11.012
- Martin B, Zimmer EI, Grimm V and Jager T (2012).
Dynamic Energy Budget theory meets individual-based
modelling: a generic and accessible implementation.
Methods Ecol Evol 3:445-449. DOI
10.1111/j.2041-210X.2011.00168.x
- Zimmer EI, Jager T, Ducrot V, Lagadic L and Kooijman
SALM (2012). Juvenile food limitation in standardized
tests - a warning to ecotoxicologists. Ecotoxicology
21:2195-2204. DOI
10.1007/s10646-012-0973-5
- Jager T (2013). All individuals are not created equal;
accounting for inter-individual variation in fitting
life-history responses to toxicants. Environ Sci Technol
47:1664-1669. DOI
10.1021/es303870g
- Jager T, Barsi A and Ducrot V (2013). Hormesis on
life-historty traits: is there such a thing as a free
lunch? Ecotoxicology 22:263-270. DOI
10.1007/s10646-012-1022-0
- Jager T, Martin BT and Zimmer EI (2013). DEBkiss or
the quest for the simplest generic model of animal life
history. J Theor Biol 328:9-18. DOI
10.1016/j.jtbi.2013.03.011
- Martin B, Jager T, Nisbet RM, Preuss TG and Grimm V
(2013). Predicting population dynamics from the
properties of individuals: a cross-level test of Dynamic
Energy Budget theory. American Naturalist
181(4):506-519. DOI
10.1086/669904
- Martin BT, Jager T, Nisbet RM, Preuss TG,
Hammers-Wirtz M and Grimm V (2013). Extrapolating
ecotoxicological effects from individuals to
populations: a generic approach based on Dynamic Energy
Budget theory and individual-based modeling.
Ecotoxicology 22:574-583. DOI
10.1007/s10646-013-1049-x
- Barsi A, Jager T, Collinet M, Lagadic L and Ducrot V
(2014). Considerations for test design to accommodate
energy-budget models in ecotoxicology: a case study for
acetone in the pond snail Lymnaea stagnalis.
Environ Toxicol Chem 33(7):1466-1475 DOI
10.1002/etc.2399
- Jager T (2014). Reconsidering sufficient and optimal
test design in acute toxicity testing. Ecotoxicology
23(1):38-44 DOI
10.1007/s10646-013-1149-7
- Jager T, Barsi A, Hamda NT, Martin BT, Zimmer EI and
Ducrot V (2014). Dynamic energy budgets in population
ecotoxicology: applications and outlook. Ecol Mod
280:140-147 DOI
10.1016/j.ecolmodel.2013.06.024
- Martin B, Jager T, Nisbet RM, Preuss TG and Grimm V
(2014). Limitations of extrapolating toxic effects on
reproduction to the population level. Ecol Appl
24(8):1972-1983 DOI
10.1890/14-0656.1
- Zimmer EI, Ducrot V, Jager T, Koene J, Lagadic L and
Kooijman SALM (2014). Metabolic acceleration in the pond
snail Lymnaea stagnalis? J Sea Res 94:84-91 DOI
10.1016/j.seares.2014.07.006
- ...
Output: Presentations (as presenter and as contributor)
Too many to count ... ;-)
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